Science
BlossomHill is designing and developing medicines to address significant unmet medical needs in cancer treatment.
Despite significant advances in cancer therapy and precision medicine, cures remain elusive due to cancer’s remarkable ability to develop tolerance and resistance to treatments, one of the toughest and most important problems to solve for patients.
Cancer’s resistance comes in two primary forms:
On-Target Resistance
Cancer cells mutate the very targets that drugs aim to attack, rendering the drugs less effective.
OFF-Target Resistance
Cancer evolves to bypass the pathway involved in a treatment by activating alternative signaling pathways as a way to survive.
BlossomHill aims to develop treatments that consider the full spectrum of its survival mechanisms.
By developing treatments designed to counteract both known and potential future resistance mechanisms, we aim to deliver therapies with the potential to meaningfully improve outcomes for cancer patients.